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Wednesday, May 6, 2020 | History

4 edition of Bacterial Superantigens / Structure, Function, and Therapeutic Potential found in the catalog.

Bacterial Superantigens / Structure, Function, and Therapeutic Potential

Bacterial Superantigens / Structure, Function, and Therapeutic Potential

Structure, Function, and Therapeutic Potential (Molecular Biology Intelligence Unit)

  • 305 Want to read
  • 2 Currently reading

Published by R G Landes Co .
Written in English

    Subjects:
  • physiology,
  • Antigens,
  • Superantigens,
  • Antigens, Bacterial,
  • Medical Immunology,
  • Bacterial antigens,
  • Science/Mathematics

  • Edition Notes

    ContributionsRafick-Pierre Sekaly (Editor), Jacques Thibodeau (Editor)
    The Physical Object
    FormatHardcover
    Number of Pages241
    ID Numbers
    Open LibraryOL8697040M
    ISBN 101570592640
    ISBN 109781570592645

      Fessler J, Felber A, Duftner C, Dejaco C () Therapeutic potential of regulatory T cells in autoimmune disorders. BioDrugs – doi: /s Cited by: 2. A subpopulation of immune cells that normally fend off pathogens can turn against the host during certain infections, a new study publishing on June 20 in the open access journal PLOS Biology reveals.

    3-dimensional structure, function, and diversity of superantigens, including an account of the critical involvement of zinc in the optimal binding of some of these proteins. Section 3 contains an entire chapter that describes the pathophysiology of superantigens in both acute and chronic skin disorders. Several chapters in section 4 describe. Bacterial superantigens (Sags) constitute a family of very stable bacterial proteins that are the most potent known activators of the immune system. They can cause food poisoning or, if they occur at sufficient concentration in the blood or lymphoid tissue, systemic shock [1].

    Superantigens (SAGs) are a class of immunostimulatory and disease-causing proteins of bacterial or viral origin with the ability to activate large fractions (5–20%) of the T cell population. Activation requires simultaneous interaction of the SAG with the Vβ domain of the T cell receptor (TCR) and with major histocompatibility complex (MHC) class II molecules on the surface of an antigen Cited by:   A subpopulation of immune cells that normally fend off pathogens can turn against the host during certain infections, a new study publishing on June 20 .


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Bacterial Superantigens / Structure, Function, and Therapeutic Potential Download PDF EPUB FB2

Introduction --Bacterial Superantigens: Structure, Function and Therapeutic Potential / Jacques Thibodeau and Rafick-Pierre Sekaly Molecular Topology Is Important for the Function of Staphylococcal Superantigens / Howard S.

Tranter, Rossalyn D. Brehm and K. Ravi Acharya Too Many Superantigens / Bernhard Fleischer Bacterial Superantigens / Structure, Function, and Therapeutic Potential (Molecular Biology Intelligence Unit) [Jacques Thibodeau, Rafick-Pierre Sekaly] on *FREE* Bacterial Superantigens / Structure on qualifying offers.

Superantigens are microbial or viral protein toxins with potent immunostimulatory properties. These properties are attributable to their unique ability to crosslink major histocompatibility complex (MHC) class II molecules with T cell receptors (TCRs), forming a trimolecular complex that activates a much larger number of resting T cells (as many as one in five T cells) than does a Cited by: Superantigens is the first comprehensive examination of these fascinating proteins ever published.

Organized into five sections and sixteen chapters, this volume provides an essential overview of many aspects of superantigen biology. A team of internationally respected researchers covers the basic molecular mechanisms of superantigen action, their structure and function, and their role in.

bacterial superantigens structure function and therapeutic potential molecular biology intelligence unit Posted By Roger Hargreaves Media TEXT ID ebd4d7 Online PDF Ebook Epub Library factor across a spectrum of psychiatric disorders a role supported by a growing body of biological studies making the disc1 protein interaction network an attractive.

INTRODUCTION. Superantigens (SAgs) are the most powerful T cell mitogens ever discovered. Concentrations of less than 01 pg/ml of a bacterial superantigen are sufficient to stimulate the T lymphocytes in an uncontrolled manner resulting in fever, shock and death [1–3].SAgs bind, as intact molecules to the class II major histocompatibility complex (MHC) antigens expressed on professional.

Superantigens (SAgs) are a class of antigens that result in excessive activation of the immune ically it causes non-specific activation of T-cells resulting in polyclonal T cell activation and massive cytokine release.

SAgs are produced by some pathogenic viruses and bacteria most likely as a defense mechanism against the immune system. John R. Rodgers, Robert R. Rich, in Clinical Immunology (Fourth Edition), Superantigens “ Superantigens ” are microbial proteins that bind both class II MHC molecules and TCR, causing activation of the T cell.

Superantigens include certain bacterial toxins, such as staphylococcal enterotoxin A (SEA) and toxic shock syndrome toxin (TSST), and viral proteins such as the mouse mammary. Bacterial superantigens are potent T-cell stimulatory protein molecules produced by Staphylococcus aureus and Streptococcus pyogenes 1.

Their function in the microbe appears primarily to debilitate the host sufficiently through their effects on cells of the immune system to permit the causation of disease ().Their superantigenic activity can be attributed to their ability to bind to both major. Superantigens: Structure-function relationships Article Literature Review in International Journal of Medical Microbiology () May with 7 Reads How we measure 'reads'.

The structure and function of the superantigens has revealed a common architecture that is also shared by another group of staphylococcal virulence factors called the superantigen-like proteins (SSL). Author(s): Thibodeau,Jacques; Sékaly,Rafick-Pierre Title(s): Bacterial superantigens: structure, function, and therapeutic potential/ [edited by] Jacques.

Viral Superantigens in Humans: A Potential Role in HIV and CMV Infection, David N. Posnett Superantigens in Autoimmunity: Their Role as Etiologic and Therapeutic Agents, Joel Schiffenbauer, Howard Johnson, and Jeanne Soos Superantigens in Inflammatory Skin Diseases: A Role in Disease Maintenance and Induction, David A.

Norris and Donald Y. Leung. This book contains chapters devoted to individual toxins, as well as chapters that consider the different applications of these toxins. Considerable progress has been made in understanding the structure, function, interaction and trafficking into cells, as well as mechanism of action of toxins.

Get this from a library. Superantigens: molecular biology, immunology, and relevance to human disease. [Donald Y M Leung; Brigitte T Huber; Patrick M Schlievert;] -- This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases.

Superantigens are a class of antigens that cause non-specific T-cell activation, and massive release of immune cytokines. Superantigens are able to activate up to 20 percent of the body's T-cells, which would explain the link between respiratory and skin allergies, and.

Binding Kinetics of Superantigen with TCR and MHC Class II Structural features of T cell receptor recognition of superantigens, in Bacterial Superantigens: Structure, Function and Therapeutic Potential (Thibodeau, J. and H., Parker, D., White, J., Marrack, P., and Kappler, J.

() Multiple binding sites for bacterial superantigens on Author: Alam, Nicholas R. Gascoigne. Finally, the loss of sialic acid and the exposure of side chain sugars may also offer an additional recognition mechanism.

With a least three potential mechanisms available for the recognition of apoptotic cells, which is the most important in the immune system. Well, you have got to buy the book to discover the answer to this question!Author: Tom Cotter. Superantigens: Molecular Biology: Immunology, and Relevance to Human Disease: This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases.

(RHD), and M protein immunological characteristics and potential Cited by: Learn superantigens with free interactive flashcards.

Choose from 21 different sets of superantigens flashcards on Quizlet. Historical evidence suggested that treatment with superantigens might be of potential therapeutic value for cancer patients.

Over yrs ago William B. Coley administered heat-killed bacterial cultures to cancer patients (82). Bacterial superantigens turn our immune cells to the dark side Date: J Source: PLOS Summary: A subpopulation of immune cells that normally fend off pathogens can turn against the host.Toxic shock syndrome (TSS) is a serious acute bacterial disease characterized by fever, diffuse erythematous rash, hypotension, multiorgan involvement, and desquamation of the skin one to two weeks after onset.

Various immunomodulatory agents and antisuperantigen therapeutic strategies have been proposed. One such strategy includes the administration of intravenous polyspecific immunoglobulin Cited by: 2.